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Heroin

Basic Information

Summary

A powerful opioid drug derived from Morphine, with two to four times the potency. Also known as diacetylmorphine. Infamous for its high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 while trying to find a less addictive alternative to Morphine. One of the most popular drugs of all time.

Opioid

Opioids are pain-killing depressants which may also cause euphoria.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Common

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Insufflated
Light7.5-20mg
Common20-35mg
Strong35-50mg
Heavy50-75mg
Smoked
Light5-15mg
Common15-25mg
Heavy30-50mg
Intravenous
Common5-10mg
Strong8-15mg

Note: Heroin dose varies greatly depending on quality and tolerance.

Duration

Insufflated
Onset10-15 minutes
Duration3-6 hours
After-effects1-24 hours
IV
Onset0-5 minutes
Duration4-5 hours
After-effects1-24 hours
Smoked
Onset5-10 minutes
Duration3-5 hours
After-effects1-24 hours

Aliases

diamorphine

Marquis

Deep purplish red

Bioavailability

Oral 35% | Intramuscular 85%

Half-life

2-3 minutes

Effects

Euphoria, Dry Mouth, Mood lift, Itchiness, Relaxant, Constipation, Pupil Constriction, Analgesia.

See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • Ketamine
    • Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
  • MXE
    • This combination can potentiate the effects of the opioid
  • DXM
    • CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
  • Cocaine
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  • Alcohol
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
  • GHB/GBL
    • The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
  • Tramadol
    • Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
  • Benzodiazepines
    • Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

Caution

  • PCP
    • PCP can reduce opioid tolerance, increasing the risk of overdose
  • N2O
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
  • Amphetamines
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  • MAOIs
    • Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.

Low risk & Increased Effects

Low risk & No Synergy

  • Mushrooms
  • LSD
  • DMT
  • Mescaline
  • DOx
    • No unexpected interactions.
  • NBOMes
  • 2C-x
  • 2C-T-x
    • No expected interactions, some opioids have serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
  • ╬▒MT
    • No unexpected interactions
  • 5-MeO-xxT
  • MDMA
  • Caffeine
  • SSRIs
    • There have been very infrequent reports of a risk of serotonin syndrome with this combination, though this should not be a practical concern.

References & Notes

General