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Lorazepam

Basic Information

Summary

An intermediate acting benzodiazepine commonly known as Ativan, commonly prescribed as an alternative to Xanax. Sedating, hypnotic and anxiolytic. Potential to induce amnesia and lowered inhibitions in overdose. Do not combine with other depressants.

Benzodiazepine

Benzodiazepines are generally hypnotic or anxiolytic depressant drugs.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Common

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Oral
Light0.5mg-1mg
Common1-2mg
Strong2-4mg
Intramuscular
Light0.25-0.5mg
Common0.5-1mg
Strong1-2mg

NOTE: Warning - higher doses increase the chances of blacking out. Also 1mg Lorazepam ~= 10mg Diazepam.

Duration

All ROAs
Onset5-30 minutes
Duration4-8 hours
After-effects1-12 hours

Effects

Anxiolytic, sedative, high muscle relaxant properties.

Aliases

ativan

Bioavailability

Oral 85-90% | Insufflated 76-80%

Dose_to_diazepam

Lorazepam - 1mg ~=10mg Diazepam.

See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • Alcohol
    • Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
  • GHB/GBL
    • The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
  • Opioids
    • Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely
  • Tramadol
    • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.

Unsafe

  • PCP
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely

Caution

  • Ketamine
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
  • MXE
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.
  • DXM
    • Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.

Low risk & Increased Effects

Low risk & Decreased Effects

Low risk & No Synergy

References & Notes

General