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Tramadol

Basic Information

Summary

A synthetic opioid analgesic, Tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.

Opioid

Opioids are pain-killing depressants which may also cause euphoria.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Common

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Oral
Light50-100mg
Common100-250mg
Heavy250-400mg

NOTE: Tramadol has a ceiling dose, where recreational effects are not increased. Risk of seizure at doses over 350mg. Tramadol decreases the seizure threshold, use extreme caution. Dosing insufflated is ineffective.

Duration

All ROAs
Onset1 hours
Duration5-7 hours
After-effects1-12 hours

Effects

euphoria, elevated mood, overall feeling of contentedness, itching, drowsiness, vomiting, urinary retention, nausea, constipation, risk of seizure above 300mg

Avoid

benzos, alcohol, and other opiates

Bioavailability

Oral 68-72% | Rectal 77%

Aliases

tram

See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • ╬▒MT
  • Ketamine
  • MXE
  • DXM
  • PCP
  • Amphetamines
    • Tramadol and stimulants both increase the risk of seizures.
  • MDMA
    • Tramadol and stimulants both increase the risk of seizures.
  • Cocaine
    • Tramadol and stimulants both increase the risk of seizures.
  • Alcohol
    • Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
  • GHB/GBL
    • The sedative effects of this combination can lead to dangerous respiratory depression.
  • Opioids
    • Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
  • Benzodiazepines
    • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.
  • MAOIs
  • SSRIs

Unsafe

  • Mushrooms
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
  • LSD
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
  • DMT
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
  • Mescaline
    • This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.
  • DOx
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
  • NBOMes
    • Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures
  • 2C-x
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
  • 2C-T-x
  • 5-MeO-xxT

Caution

  • N2O
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.

Low risk & Increased Effects

Low risk & No Synergy

References & Notes

General